inhibition of murine systemic leishmaniasis by acetyl salicylic acid via nitric oxide immunomodulation

Inhibition of Murine Systemic Leishmaniasis by Acetyl Salicylic Acid via Nitric Oxide Immunomodulation

BACKGROUND The purpose of this study was to evaluate antileishmanial effects of ASA via NO pathway in Leishmania major infected Balb/c mice. Moreover, toxicity and pathological consequences of ASA administration were investigated. METHODS Balb/c mice were infected with L. major and ASA was inoculated orally after lesion appearance for its ability to modulate NO and to modify Leishmania infect...

Salicylic acid activates nitric oxide synthesis in Arabidopsis.

The relationship between nitric oxide (NO) and salicylic acid (SA) was investigated in Arabidopsis thaliana. Here it is shown that SA is able to induce NO synthesis in a dose-dependent manner in Arabidopsis. NO production was detected by confocal microscopic analysis and spectrofluorometric assay in plant roots and cultured cells. To identify the metabolic pathways involved in SA-induced NO syn...

Nitric oxide and salicylic acid signaling in plant defense.

Salicylic acid (SA) plays a critical signaling role in the activation of plant defense responses after pathogen attack. We have identified several potential components of the SA signaling pathway, including (i) the H(2)O(2)-scavenging enzymes catalase and ascorbate peroxidase, (ii) a high affinity SA-binding protein (SABP2), (iii) a SA-inducible protein kinase (SIPK), (iv) NPR1, an ankyrin repe...

Synthesis and Analysis of Acetyl Salicylic Acid

Inhibition of ethylene biosynthesis by salicylic Acid.

Salicylic acid inhibited ethylene formation from ACC in self-buffered (pH 3.8) pear (Pyrus communis) cell suspension cultures with a K(1) (app) of about 10 micromolar after 1 to 3 hours incubation. Inhibition appeared noncompetitive. Among 22 related phenolic compounds tested, only acetylsalicylic acid showed similar levels of inhibition. Inhibition by salicylic acid was inversely dependent on ...

Pretreatment with salicylic acid and nitric oxide alleviates silver nanoparticles toxicity in medicinal Hypericum perforatum plants

Since the use of seed priming agents to reduce the potential toxicity of AgNPs has not been explored, we evaluated the combined effects of 0.1 mM salicylic acid (SA) and 0.1 mM nitric oxide (NO) on responses of Hypericum perforatum plants to Ag-induced stress. The results of growth parameters together with measurement of malondialdehyde (MDA) revealed that exposure to AgNPs or AgNO3 caused more...